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Review
. 2013;27(5):281-5.
doi: 10.1155/2013/138673.

Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection

Nathan K Ho  1 , Aleah C Henry, Kathene Johnson-Henry, Philip M Sherman
Affiliations
Review

Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection

Nathan K Ho et al. Can J Gastroenterol. 2013.

Abstract
in English, French

Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.

L’Escherichia coli de sérotype O157:H7 entérohémorragique est un pathogène d’origine alimentaire et hydrique qui provoque une morbidité et une mortalité considérables, tant dans les pays en développement que dans les pays industrialisés. La présente analyse s’attarde sur l’histoire, l’épidémiologie et l’évolution du pathogène, présente un aperçu mécaniste des principaux facteurs de virulence (y compris les toxines Shiga, les îlots de pathogénicité du locus d’effacement des entérocytes et le plasmide pO157), aborde les réponses immunitaires de l’hôte à l’infection, traite des modèles animaux disponibles et contient un aperçu de la prise en charge actuelle et éventuelle.

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Figures

Figure 1)
Figure 1)
Summary of Escherichia coli O157:H7 infection including the source of infection, potential routes of human contamination, sites of infection and injury, major presenting clinical features and potential short-term complications. IBS Irritable bowel syndrome
See this image and copyright information in PMC

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