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. 1990 Jan;84(1):67-70.
doi: 10.1016/s0954-6111(08)80097-2.

Compliance with inhaled therapy and morbidity from asthma

C R Horn  1 , T J Clark, G M Cochrane
Affiliations

Compliance with inhaled therapy and morbidity from asthma

C R Horn et al. Respir Med. 1990 Jan.

Abstract

Patient compliance with a standardized incremental regimen of inhaled anti-asthma therapy has been assessed in a large, prospective study in general practice. Urine salbutamol estimations were made in 30 patients who had the largest improvement with therapy (mean increase in FEV1 0.45 l above baseline: Responsive) and in 30 patients whose airflow obstruction failed to improve (FEV1-0.14 l: Nonresponsive). The urine salbutamol concentrations rose over the 9 month period in the responsive patients as expected with the incremental doses prescribed, and were significantly higher than urine levels in nonresponsive patients at two dose levels. Poor compliance with prescribed inhaled therapy is an important cause of persistent morbidity from asthma.

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