Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials
- PMID: 23714269
- DOI: 10.1016/j.hrtlng.2013.03.006
Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials
Abstract
Introduction: Omega-3 polyunsaturated fatty acids (PUFA) have demonstrated to have antiarrhythmic properties. However, randomized studies have shown inconsistent results.
Objective: We aimed to analyze the effect of omega-3 PUFA on preventing potentially fatal ventricular arrhythmias and sudden cardiac death.
Methods: Randomized trials comparing omega-3 PUFA to placebo and reporting sudden cardiac death (SCD) or first implanted cardioverter-defibrillator (ICD) event for ventricular tachycardia or fibrillation were included in this study. A meta-analysis using a random effects model was performed and results were expressed in terms of Odds Ratio (OR) and 95% Confidence Interval (CI) after evaluating for interstudy heterogeneity using I(2). The reported data were extracted on the basis of the intention-to-treat principle.
Results: A total of 32,919 patients were included in nine trials; 16,465 patients received omega-3 PUFA and 16,454 received placebo. When comparing omega-3 PUFA to placebo, there was nonsignificant risk reduction of SCD or ventricular arrhythmias (OR = 0.82 [95% CI: 0.60-1.21], p = 0.21 I(2) = 49.7%).
Conclusion: Dietary supplementation with omega-3 PUFA does not affect the risk of SCD or ventricular arrhythmias.
Keywords: Arrhythmias; Dietary supplements; Fish oil; Sudden cardiac death.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment in
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Omega-3 polyunsaturated fatty acids for patients at risk of sudden cardiac death and ventricular arrhythmias: trial sequential analysis.Heart Lung. 2013 Sep-Oct;42(5):391-2. doi: 10.1016/j.hrtlng.2013.06.002. Epub 2013 Jul 9. Heart Lung. 2013. PMID: 23849506 No abstract available.
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Applying trial sequential analysis on a negative meta-analysis: where is the real benefit?Heart Lung. 2013 Sep-Oct;42(5):392-3. doi: 10.1016/j.hrtlng.2013.06.048. Epub 2013 Jul 12. Heart Lung. 2013. PMID: 23850292 No abstract available.
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