Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar-Apr;45(2):155-8.
doi: 10.4103/0253-7613.108299.

Drug-drug interaction between voriconazole and oral hypoglycemic agents in diabetic rats

Boyina Hemanth Kumar  1 , Bheemachari Joshi, Jayasingh Chellammal Hanish Singh, Prakash V Diwan
Affiliations

Drug-drug interaction between voriconazole and oral hypoglycemic agents in diabetic rats

Boyina Hemanth Kumar et al. Indian J Pharmacol. 2013 Mar-Apr.

Abstract

Objective: The objective was to study the of drug-drug interaction between voriconazole and oral hypoglycemic agents in normal and alloxan induced diabetic rats.

Materials and methods: The study was designed in two phases. In the first phase, influence of glibenclamide (0.45 mg/kg, p.o.) and pioglitazone (2.7 mg/kg, p.o. once daily) on blood glucose levels in normoglycemic rats was studied and then influence of voriconazole (18 mg/kg, p.o. twice daily.) pre-treatment on the hypoglycemic activity studied. Simultaneously the influence of voriconazole treatment for seven consecutive days (per se effect) on blood glucose levels was also studied in normoglycemic rats. In the second phase of the study alloxan-induced diabetic rats were used to find out the influence of voriconazole pre-treatment on glibenclamide and pioglitazone induced hypoglycemic effect in pathophysiological condition. Blood samples were collected from retro orbital plexus at regular intervals of 0.0, 0.5, 1.0, 2.0, 4.0, 8.0, 12.0, 18.0 and 24.0 h after drug treatment. All the blood samples were analyzed for plasma glucose by glucose oxidase peroxidase method (GOD/POD).

Results: The therapeutic dose of voriconazole potentiates the hypoglycemic activity of glibenclamide and pioglitazone both in normoglycemic and diabetic rats respectively.

Conclusion: The results indicate that the dose of oral hypoglycemic agents needs to be adjusted if co-administered with voriconazole.

Keywords: Drug-drug interaction; glibenclamide; hypoglycemic; pioglitazone; voriconazole.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Effect of Voriconazole (18 mg/kg) on Glibenclamide (0.45 mg/kg) induced hypoglycemia in normoglycemic rats
Figure 2
Figure 2
Effect of Voriconazole (18 mg/kg) on Pioglitazone (2.7 mg/kg) induced hypoglycemia in normoglycemic rats
Figure 3
Figure 3
Effect of Voriconazole (18 mg/kg) on Glibenclamide (0.45 mg/kg) induced hypoglycemia in diabetic rats
Figure 4
Figure 4
Effect of Voriconazole (18 mg/kg) on Pioglitazone (2.7 mg/kg) induced hypoglycemia in diabetic rats
See this image and copyright information in PMC

References

    1. Al-Attas SA, Amro SO. Candidal colonization, strain diversity, and anti-fungal susceptibility among adult diabetic patients. Ann Saudi Med. 2010;30:101–8. - PMC - PubMed
    1. Chellan G, Shivaprakash S, Karimassery RS, Varma AK, Varma N, Thekkeparambil SM, et al. Spectrum and prevalence of fungi infecting deep tissues of lower-limb wounds in patients with type 2 diabetes. J Clin Microbiol. 2010;48:2097–102. - PMC - PubMed
    1. Rajagopalan S. Serious infections in elderly patients with diabetes mellitus. Clin Infect Dis. 2005;40:990–6. - PubMed
    1. Herbrecht R. Voriconazole: therapeutic review of a new azole anti-fungal. Expert Rev Anti Infect Ther. 2004;2:485–97. - PubMed
    1. Lat A, Thompson GR., 3rd Update on the optimal use of voriconazole for invasive fungal infections. Infect Drug Resist. 2011;4:43–53. - PMC - PubMed

MeSH terms