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Case Reports
. 2012 Sep;18(3):369-72.
doi: 10.4103/0971-6866.108050.

A novel 11;18 translocation in a case of acute myeloid leukemia with maturation

Devi G Sandhya  1 , Faiq Ahmed, Kavita Khadke, Sudha S Murthy, Senthil J Rajappa
Affiliations
Case Reports

A novel 11;18 translocation in a case of acute myeloid leukemia with maturation

Devi G Sandhya et al. Indian J Hum Genet. 2012 Sep.

Abstract

Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2.

Keywords: Acute myeloid leukemia with maturation 2; CD82; GATA6; chromosomal abnormality; immunophenotyping; translocation 11;18.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Peripheral smear of an AML-M2 case showing blast with Auer rods
Figure 2
Figure 2
Myeloperoxidase highlighting Auer rods within the blast
Figure 3
Figure 3
Scatter plots on immunophenotyping - the gated population of neoplastic cells showed bright positivity for HLA-DR, moderate positivity for CD34, CD33, dim to moderate for CD117, CD13 negativity for CD10, CD19, CD7, CD22, CD5, CD2, CD14, CD56
Figure 4
Figure 4
Karyotype of AML M2 case showing 46,XY, + 6,t(11;18)(p11.2;q11.2)
See this image and copyright information in PMC

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