Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;36(4):369-74.
doi: 10.5142/jgr.2012.36.4.369.

Inhibitory effects of ginsenoside re isolated from ginseng berry on histamine and cytokine release in human mast cells and human alveolar epithelial cells

Hye Min Bae  1 , Ok Sun Cho, Shin Jung Kim, Byung Ok Im, Soon Hyun Cho, Sena Lee, Myung-Gyou Kim, Kyung Tack Kim, Kang Hyun Leem, Sung Kwon Ko
Affiliations

Inhibitory effects of ginsenoside re isolated from ginseng berry on histamine and cytokine release in human mast cells and human alveolar epithelial cells

Hye Min Bae et al. J Ginseng Res. 2012 Oct.

Abstract

The berry of Panax ginseng significantly inhibited the histamine releases at the concentration of 30 μg/mL (p<0.05) and 10 μg/mL (p<0.01). The ginsenoside Re from ginseng berry was found out to have a potent effect in the experiment of histamin and cytokine release.

Keywords: Cytokine; Ginseng berry; Ginsenoside Re; Histamine; Panax ginseng.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.. Photograph of ginseng berry (A) and histamine content of cultured supernatants of human mast cells (B). Blank group was not incubated with compound 48/80, and other experimental groups were incubated with compound 48/80 (*p<0.05, **p<0.01 vs. control).
Fig. 2.
Fig. 2.. Microphotographs of degranulation in human mast cells. (A) An unstimulated mast cell. (B) The cell has been activated to secrete its stored histamine by compound 48/80. (C) The extracts of ginseng berry (30 μg/mL) prevented the histamine secretion induced by compound 48/80.
Fig. 3.
Fig. 3.. Chemical structures of compound I (A) and histamine content of cultured supernatants of human mast cells (B). Blank group was not incubated with compound 48/80, however, other experimental groups were incubated with compound 48/80 (*p<0.05, **p<0.01 vs. control).
Fig. 4.
Fig. 4.. (A-D) Cytokine array photo graphs and quantitatively analyzing graphs. A549 cells were incubated lipopolysaccharide (LPS) and/or each sample (*p<0.05 vs. LPS treated control). RANTES, regulated and normal T cell expressed and secreted.
See this image and copyright information in PMC

References

    1. Kitagawa I, Taniyama T, Shibuya H, Noda T, Yoshikawa M. Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. Yakugaku Zasshi. 1987;107:495–505. - PubMed
    1. Namba T. The encyclopedia of Wakan-Yaku with color pictures. Hoikusha Publishing Co.; Osaka: 1980.
    1. Park JD. Recent studies on the chemical constituents of Korean ginseng (Panax ginseng C. A. Meyer). Korean J Ginseng Sci. 1996;20:389–415.
    1. Sanada S, Kondo N, Shoji J, Tanaka O, Shibata S. Studies on the saponins of ginseng. I. Structures of ginsenoside- Ro,-Rb1,-Rb2,-Rc and -Rd. Chem Pharm Bull (Tokyo) 1974;22:421–428.
    1. Shibata S, Tanaka O, Ando T, Sado M, Tsushima S, Ohsawa T. Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins. Chem Pharm Bull (Tokyo) 1966;14:595–600. - PubMed

LinkOut - more resources