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. 2013 May;9(5):e1003537.
doi: 10.1371/journal.pgen.1003537. Epub 2013 May 23.

From paramutation to paradigm

Ian R Adams  1 , Richard R Meehan
Affiliations

From paramutation to paradigm

Ian R Adams et al. PLoS Genet. 2013 May.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mammalian paramutation.
RNA generated from a paramutagenic allele (blue/yellow) is processed and methylated in a Dnmt2-dependent manner (red circles) in the parental germline, which in turn induces a heritable change in the expression level of the wild-type copy of that allele (blue) in the offspring. The article by Kiani et al. in this issue of PLOS Genetics places the RNA methyltransferase Dnmt2 at the heart of the mammalian paramutation mechanism.
See this image and copyright information in PMC

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