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Case Reports
. 2013 May 9:7:316.
doi: 10.3332/ecancer.2013.316. Print 2013.

Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: a case report and literature review

Sandhya Tamgadge  1 , Avinash Tamgadge, Neha Modak, Sudhir Bhalerao
Affiliations
Case Reports

Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: a case report and literature review

Sandhya Tamgadge et al. Ecancermedicalscience. .

Abstract

Primary intraosseous squamous cell carcinoma (PIOSCC) derived from an odontogenic keratocyst (OKC) is a rare malignant neoplasm of the jaws, which is locally aggressive with quite poor prognosis. The incidence of carcinomas arising in odontogenic cysts was reported to be approximately 1-2/1000. The number of well-documented cases of PIOSCC ex OKC is extremely small; hence, no sufficient incidence data are available in the literature. Overall, the survival rate of an individual, which is a period of two years, is very poor, and this can be attributed to the delayed diagnosis. But knowledge of the histopathological and immunohistological features of PIOSCC allows accurate and early diagnosis of the lesion so that an early and appropriate treatment can be instituted for better prognosis. The following report describes an extremely rare case of PIOSCC of the mandible derived from an OKC in a 20-year-old female patient.

Keywords: Carnoy’s solution; mandible; odontogenic keratocyst; p53; primary intraosseous squamous cell carcinoma.

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Figures

Figure 1:
Figure 1:. Extraoral photograph showing diffuse swelling on left side of the mandible, with facial asymmetry
Figure 2:
Figure 2:. Intraoral photograph showing obliteration of left buccal sulcus
Figure 3:
Figure 3:. Panoramic radiograph showing multilocular radiolucent lesion in ascending ramus
Figure 4:
Figure 4:. CT scan showing expansion and perforation of buccal and lingual cortical plates
Figure 5:
Figure 5:. Photomicrograph showing the transition of OKC into SCC (lumen (L), epithelial lining (E), keratin pearl (K), epithelial lining proliferating into connective tissue capsule (P), odontogenic islands (O), and inductive changes (I, inset))
Figure 6:
Figure 6:. Odontogenic epithelium showing mural proliferation in the form of odontogenic islands. The inset shows the odontogenic islands at a higher magnification
Figure 7:
Figure 7:. Photomicrograph showing features of malignancy: (A) odontogenic islands with mitotic figures, (B) dystrophic calcification, (C) areas of necrosis, and (D) angiogenesis associated with odontogenic islands
Figure 8:
Figure 8:. Photomicrograph showing positive p53 staining in the invading odontogenic islands
See this image and copyright information in PMC

References

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