Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;4(Suppl 1):S78-84.

Effect of resistance training on plasma nitric oxide and asymmetric dimethylarginine concentrations in type I diabetic rats

Parivash Shekarchizadeh Esfahani  1 , Reza Gharakhanlou, Jahangir Karimian, Majid Khazaei, Awat Feizi, Alireza Safarzade
Affiliations

Effect of resistance training on plasma nitric oxide and asymmetric dimethylarginine concentrations in type I diabetic rats

Parivash Shekarchizadeh Esfahani et al. Int J Prev Med. 2013 Apr.

Abstract

Background: Asymmetric dimethylarginine (ADMA) has a predominant role in progression of some cardiovascular diseases, including diabetes. It interferes with L-arginine in production of nitric oxide (NO) by inhibition of NO synthase. The purpose of this study was to evaluate the effect of resistance training on plasma NO and ADMA concentrations in type 1 diabetic male rats.

Methods: Thirty-six male wistar rats were randomly divided into four groups: (1) control; (2) diabetic; (3) diabetic trained, and (4) control trained (n = 9 each). In the trained groups, the animals undertook one training session per day, 3 days/week, for 4 weeks. At the end of experiment, blood samples were taken and the concentrations of plasma glucose, insulin, lipid profile, NO and ADMA concentrations were determined.

Results: plasma ADMA concentration showed a significant increase in diabetic rats compare to control group (0.73 ± 0.07 vs. 0.62 ± 0.04 μmol/l; P < 0.05). The plasma ADMA level in the trained diabetic and control were lower than the sedentary groups, although it was not statistically significant. Plasma NO concentration in diabetic group was lower than control (P < 0.05). Resistance training significantly increased plasma NO concentration in diabetic animals (P < 0.05).

Conclusion: Elevated ADMA level in diabetic animals can normalize during resistance exercise. Reduced ADMA level and increased NO level following resistance training might improve cardiovascular risk in diabetic subjects.

Keywords: Asymmetric dimethylarginine; diabetes; nitric oxide; resistance training.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Plasma ADMA concentrations in experimental groups (n = 9 in each group)
Figure 2
Figure 2
Plasma nitric oxide (NO) concentrations before and after experiment in study groups (n = 9 in each group). *: P<0.05 compare to other groups
See this image and copyright information in PMC

References

    1. Leiper J, Vallance P. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res. 1999;43:542–8. - PubMed
    1. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524–6. - PubMed
    1. Vallance P, Chan N. Endothelial function and nitric oxide: Clinical relevance. Heart. 2001;85:342–50. - PMC - PubMed
    1. Böger RH. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the “L-arginine paradox” and acts as a novel cardiovascular risk factor. J Nutr. 2004;134:2842S–7. - PubMed
    1. Altinova AE, Arslan M, Sepici-Dincel A, Akturk M, Altan N, Toruner FB. Uncomplicated type 1 diabetes is associated with increased asymmetric dimethylarginine concentrations. J Clin Endocrinol Metab. 2007;92:1881–5. - PubMed

LinkOut - more resources