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. 2013 Jun 12;135(23):8436-9.
doi: 10.1021/ja404217t. Epub 2013 Jun 3.

Copper-promoted Sandmeyer trifluoromethylation reaction

Jian-Jun Dai  1 , Chi Fang, Bin Xiao, Jun Yi, Jun Xu, Zhao-Jing Liu, Xi Lu, Lei Liu, Yao Fu
Affiliations

Copper-promoted Sandmeyer trifluoromethylation reaction

Jian-Jun Dai et al. J Am Chem Soc. .

Abstract

A copper-promoted trifluoromethylation reaction of aromatic amines is described. This transformation proceeds smoothly under mild conditions and exhibits good tolerance of many synthetically relevant functional groups. It provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes. It also constitutes a new example of the Sandmeyer reaction.

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