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Review
. 2013 Apr;3(2):957-76.
doi: 10.1002/cphy.c120028.

Immune and inflammatory role in renal disease

John D Imig  1 , Michael J Ryan
Affiliations
Review

Immune and inflammatory role in renal disease

John D Imig et al. Compr Physiol. 2013 Apr.

Abstract

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and immune system activation as a common underlying mechanism. The purpose of this review is to provide a broad overview of immune cells and inflammatory proteins that contribute to the pathogenesis of renal disease, and to discuss some of the physiological changes that occur in the kidney as a result of immune system activation. An overview of common forms of acute and chronic renal disease is provided, followed by a discussion of common therapies that have anti-inflammatory or immunosuppressive effects in the treatment of renal disease.

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Figures

Figure 1
Figure 1
Immune system activation and inflammation have a central role in the pathogenesis of acute kidney injury (AKI) and chronic kidney disease (CKD).
Figure 2
Figure 2
Immune system components and proteins implicated in the pathogenesis of renal disease. The overlap represents components involved in cross-talk between innate and adaptive immunity.
Figure 3
Figure 3
Schematic of inflammatory events involved in the progression of diabetic nephropathy.
Figure 4
Figure 4
Schematic of contribution of T cells and cytokines in hypertension.
Figure 5
Figure 5
Schematic of inflammatory events involved in the progression of renal disease.
See this image and copyright information in PMC

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