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. 2013 May;58(3):242.
doi: 10.4103/0019-5154.110858.

Cheilitis granulomatosa: a case report with review of literature

Nupura A Vibhute  1 , Aniket H Vibhute, Nilima R Daule
Affiliations

Cheilitis granulomatosa: a case report with review of literature

Nupura A Vibhute et al. Indian J Dermatol. 2013 May.

Abstract

Cheilitis granulomatosa (CG) is a chronic swelling of the lip due to granulomatous inflammation. It is a rare inflammatory disorder first described by Miescher in 1945. It is a monosymptomatic form or an incomplete variant of Melkersson-Rosenthal syndrome; a triad of recurrent orofacial edema, recurrent facial nerve palsy and fissuring of the tongue. As the etiology remains unknown, treatment of CG is challenging. We present a case of CG in a 43-year-old female patient secondary to allergy to certain food items. The present case highlights the importance of thorough investigations in the diagnosis of this lesion as the findings mimic many other granulomatous conditions.

Keywords: Cheilitis granulomatosa; Melkersson-Rosenthal syndrome; lip swelling.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Patient with upper lip swelling and peeling in perioral area
Figure 2
Figure 2
Upper lip and perioral area showing swelling and areas of crusting and fissuring
Figure 3
Figure 3
Section showing hyperplastic epithelium and dense inflammatory infiltrate in underlying connective tissue (H and E, ×10)
Figure 4
Figure 4
Section under higher magnification showing fibrocellular connective tissue with abundant non - caseating granulomas with Langhans type multinucleated giant cells (H and E, ×40)
See this image and copyright information in PMC

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