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. 2013 Mar;26(1):51-3.
doi: 10.1293/tox.26.51. Epub 2013 Apr 22.

A case of feline gastrointestinal eosinophilic sclerosing fibroplasia

Manabu Suzuki  1 , Miyako Onchi, Masakazu Ozaki
Affiliations

A case of feline gastrointestinal eosinophilic sclerosing fibroplasia

Manabu Suzuki et al. J Toxicol Pathol. 2013 Mar.

Abstract

Feline gastrointestinal eosinophilic sclerosing fibroplasia was diagnosed in an 8-month-old Scottish fold that had a primary gastrointestinal mass involving the stomach, duodenum and mesenteric lymph nodes. Histopathologically, the most characteristic feature of this mass was granulation tissue with eosinophil infiltration and hyperplasia of sclerosing collagen fiber. Immunohistochemically, large spindle-shaped cells were positive for smooth muscle actin and vimentin. This case emphasizes the importance of feline gastrointestinal eosinophilic sclerosing fibroplasia as a differential diagnosis of gastrointestinal neoplastic lesions such as osteosarcoma and mast cell tumor in cats.

Keywords: cat; eosinophil; fibrosis; gastrointestinal tract; granulation tissue.

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Figures

Fig. 1.
Fig. 1.
Sclerotic collagen bundles form a branching and anastomosing trabecule pattern. H.E. ×100.
Fig. 2.
Fig. 2.
Large spindle-shaped cells proliferate in the lesion, which contains many eosinophils. H.E. ×400.
Fig. 3.
Fig. 3.
Masson’s trichrome stain revealed that the sclerosing components were collagen. Masson’s trichrome stain ×100.
See this image and copyright information in PMC

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