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Case Reports
. 2013 Jan;6(1):51-3.
doi: 10.4103/0974-2077.110101.

Pleomorphic lipoma of the tongue as potential mimic of liposarcoma

Antonio D'Antonio  1 , Giampiero Locatelli, Giuseppina Liguori, Maria Addesso
Affiliations
Case Reports

Pleomorphic lipoma of the tongue as potential mimic of liposarcoma

Antonio D'Antonio et al. J Cutan Aesthet Surg. 2013 Jan.

Abstract

We herein report a rare case of pleomorphic lipoma of the tongue with a review of world literature. A 44-year-old woman presented with a nodule of the tongue that had been present for over three years. Clinical examination revealed a yellowish sub-mucosal lesion, measuring 3 cm in maximum diameter, protruding from lingual surface. A first biopsy showed a lipomatous tumour composed of mature adipocytes intermingled with myxoid areas composed of spindle uniform in size and shape and multinucleated floret-like giant cells. Spindle and giant cells were positive for CD34. A diagnosis of pleomorphic lipoma was made. In view of the benign nature of this mass, it was de-bulked rather than completely excised in order to preserve swallowing function.

Keywords: Differential diagnosis; immunohistochemistry; pleomorphic lipoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
The mass was poor circumscribed and lipomatous in appearance with mature adipocytes, diffusely infiltrating striated muscle fibers (H and E, × 10)
Figure 2
Figure 2
Mature adipose tissue was admixed with abundant mucoid stroma (H and E, × 20)
Figure 3
Figure 3
Mucoid areas showed bland-appearing spindle cells and multinucleated giant cells with radially arranged nuclei in a “floret-like” pattern (H and E, × 20)
Figure 4
Figure 4
The spindle and giant cells were strongly positive for CD34 (immunoperoxydase, × 40)
See this image and copyright information in PMC

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