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Meta-Analysis
. 2013 May 28;8(5):e63682.
doi: 10.1371/journal.pone.0063682. Print 2013.

Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies

Shiguang Zhao  1 , Jianing Wu, Chunlei Wang, Huailei Liu, Xingli Dong, Chen Shi, Changbin Shi, Yaohua Liu, Lei Teng, Dayong Han, Xiaofeng Chen, Guang Yang, Ligang Wang, Chen Shen, Huadong Li
Affiliations
Meta-Analysis

Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies

Shiguang Zhao et al. PLoS One. .

Abstract

Background: We performed a systematic review and meta-analysis to address the (added) value of intraoperative 5-aminolevulinic acid (5-ALA)-guided resection of high-grade malignant gliomas compared with conventional neuronavigation-guided resection, with respect to diagnostic accuracy, extent of tumor resection, safety, and survival.

Methods and findings: An electronic database search of Medline, Embase, and the Cochrane Library was undertaken. The review process followed the guidelines of the Cochrane Collaboration. 10 studies matched all selection criteria, and were thus used for qualitative synthesis. 5-ALA-guided resection demonstrated an overall sensitivity of 0.87 (95% confidence interval [CI], 0.81-0.92), specificity of 0.89 (95% CI, 0.79-0.94), positive likelihood ratio (LR) of 7.62 (95% CI, 3.87-15.01), negative LR of 0.14 (95% CI, 0.09-0.23), and diagnostic odds ratio (OR) of 53.06 (95% CI, 18.70-150.51). Summary receiver operating characteristic curves (SROC) showed an area under curve (AUC) of 94%. Contrast-enhancing tumor was completely resected in patients assigned 5-ALA as compared with patients assigned white light. Patients in the 5-ALA group had higher 6-month progression free survival and overall survival than those in the white light group.

Conclusion: Based on available literature, there is level 2 evidence that 5-ALA-guided surgery is more effective than conventional neuronavigation-guided surgery in increasing diagnostic accuracy and extent of tumor resection, enhancing quality of life, or prolonging survival in patients with high-grade malignant gliomas.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram outlining the study selection process.
Figure 2
Figure 2. Evaluation of quality of included studies using the QUADAS tool.
Figure 3
Figure 3. Forest plot for diagnosis of glioblastoma multiforme in studies included in meta-analysis.
Figure 4
Figure 4. Summary receiver operating characteristic curve for diagnosis of glioblastoma multiforme.
Included studies: ①Panciani et al. ; ②Roberts et al. ; ③Diez Valle et al. ; ④Hefti et al. ; ⑤Stummer et al. .
See this image and copyright information in PMC

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