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. 2013 May 22;6(5):342-5.
Print 2013.

Preliminary study on plasma RPN concentration of patients with infantile hemangioma treated with propranolol

Ling Zhang  1 , Hua-Ming Mai, Jing Zheng, Jia-Wei Zheng, Zheng-Gang Chen, Yan-An Wang, Zhong-Ping Qin, Ke-Lei Li, Wei-En Yuan
Affiliations

Preliminary study on plasma RPN concentration of patients with infantile hemangioma treated with propranolol

Ling Zhang et al. Int J Clin Exp Med. .

Abstract

Propranolol (PRN) has recently been recommended as the first-line medicine for complicated infantile hemangiomas (IHs), because of the significant effect. However, no pharmacokinetic parameters have ever been reported for infants who receive PRN treatment for IH. In this study, we show that plasma PRN concentration is affected by the frequency of administration of PRN. A single daily administration of PRN (1 mg/kg/d) resulted in an early elevation of plasma PRN compared to a twice a day administration of the same dose. In contrast, the twice a day application resulted in a more prolonged expression at a later time-point. Our findings provide pharmacokinetic parameters of PRN action in IH for clinic.

Keywords: Infantile hemangioma; RP-HPLC; pharmacokinetics; propranolol.

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Figures

Figure 1
Figure 1
Age 2 month, no treatment.
Figure 2
Figure 2
A coronal T2-weighted MRI reveals the lesion.
Figure 3
Figure 3
Age 12 month, 10 month after starting propranolol.
Figure 4
Figure 4
PRN concentration in plasma of IH patients following oral PRN administration. The time of peak concentration; Mean plasma concentrations after a single (group qd, n=6) and twice daily (group bid, n=6) PRN application (*P<0.05).
See this image and copyright information in PMC

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