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. 2013 May 31;2(1):7.
doi: 10.1186/2046-2530-2-7.

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

Teunis Jp van Dam  1 , Gabrielle Wheway, Gisela G Slaats; SYSCILIA Study Group; Martijn A Huynen, Rachel H Giles
Affiliations

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

Teunis Jp van Dam et al. Cilia. .

Abstract

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.

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Figures

Figure 1
Figure 1
Flow diagram describing the processes to create the SCGS.
Figure 2
Figure 2
Schematic overview of ciliary components annotated in the gold standard. The schematic depiction of the eukaryotic cilium and its components as annotated in the SCGS, based on Basten et al. [36]. The pie chart represents the occurrence of ciliary component localization in the SCGS. The numbers in the individual colors represent the number of individual entries for each location. Note that many genes have been ascribed multiple localizations. SCGS, SYSCILIA gold standard.
See this image and copyright information in PMC

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