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Editorial
. 2013 Jun 1;187(11):1162-4.
doi: 10.1164/rccm.201303-0552ED.

B cells produce CXCL13 in lymphoid neogenesis during chronic obstructive pulmonary disease. The new kid on the block?

Leticia Monin, Shabaana A Khader
Editorial

B cells produce CXCL13 in lymphoid neogenesis during chronic obstructive pulmonary disease. The new kid on the block?

Leticia Monin et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

<i>Figure 1.</i>
Figure 1.
A role for CXCL13 in a feedback loop that promotes the maintenance of chronic obstructive pulmonary disease (COPD) lymphoid follicles. Lymphoid follicles with defined B- and T-cell areas, a network of follicular dendritic cells, and infiltrating dendritic cells and macrophages have been described in COPD. In these structures, CXCL13 production is instrumental for guiding T- and B-cell migration. CXCL13 signaling stimulates membrane-bound lymphotoxin expression by B cells, which in turn stimulates CXCL13 production by these cells. This positive feedback mechanism contributes to the recruitment of additional cells to lung follicles and likely promotes tertiary lymphoid organ permanence in patients with COPD. DC = dendritic cell; FDC = follicular dendritic cell; LT = lymphotoxin.
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