Comment
doi: 10.1016/j.celrep.2013.05.011.
Tumor suppression by p53: is apoptosis important or not?
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- PMID: 23726020
- DOI: 10.1016/j.celrep.2013.05.011
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Tumor suppression by p53: is apoptosis important or not?
Cell Rep.
.
Free article
Abstract
The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function.
Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Comment on
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p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.Cell Rep. 2013 May 30;3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9. Cell Rep. 2013. PMID: 23665218
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p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.Cell Rep. 2013 May 30;3(5):1512-25. doi: 10.1016/j.celrep.2013.04.008. Epub 2013 May 9. Cell Rep. 2013. PMID: 23665223
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