Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 May;100(1):150-2.
doi: 10.1111/j.1476-5381.1990.tb12067.x.

Hexocyclium derivatives with a high selectivity for smooth muscle muscarinic receptors

R Micheletti  1 , A Schiavone, E Cereda, A Donetti
Affiliations

Hexocyclium derivatives with a high selectivity for smooth muscle muscarinic receptors

R Micheletti et al. Br J Pharmacol. 1990 May.

Abstract

1. The affinity of a number of derivatives of the muscarinic antagonist, hexocyclium, containing an amidine cationic head, for guinea-pig cardiac and ileal receptors was investigated. 2. All the compounds studied displayed a greater affinity for muscular than for cardiac muscarinic receptors. 3. The 5 fold ileal selectivity of hexocyclium was increased by a number of chemical substitutions. The largest discrimination between receptors (about 200 fold) was found for the formamidine derivative. 4. The selectivity displayed by the hexocyclium derivatives stemmed from a greater decrease in affinity towards cardiac as compared to ileal receptors.

PubMed Disclaimer

References

    1. Br J Pharmacol. 1976 Dec;58(4):613-20 - PubMed
    1. Life Sci. 1986 May 5;38(18):1653-62 - PubMed
    1. Life Sci. 1986 May 5;38(18):1663-72 - PubMed
    1. Eur J Pharmacol. 1987 Sep 23;141(3):475-7 - PubMed
    1. J Med Chem. 1963 May;6:325-8 - PubMed

MeSH terms

LinkOut - more resources