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. 2013 Aug 28;337(1):115-24.
doi: 10.1016/j.canlet.2013.05.032. Epub 2013 May 29.

miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII

Ting-Hui Chu  1 , Cheng-Chieh Yang, Chung-Ji Liu, Mann-Tin Lui, Shu-Chun Lin, Kuo-Wei Chang
Affiliations

miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII

Ting-Hui Chu et al. Cancer Lett. .

Abstract

miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFβRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies.

Keywords: Carcinoma; Head and neck; TGFβRII; Transgenic mouse; c-Myc; miR-211.

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