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Review
. 2013 Aug 28;337(1):26-34.
doi: 10.1016/j.canlet.2013.05.030. Epub 2013 May 29.

P97/CDC-48: proteostasis control in tumor cell biology

Delphine Fessart  1 , Esther Marza, Saïd Taouji, Frédéric Delom, Eric Chevet
Affiliations
Review

P97/CDC-48: proteostasis control in tumor cell biology

Delphine Fessart et al. Cancer Lett. .

Abstract

P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA+ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.

Keywords: CDC-48; Cancer; Proteostasis; VCP; p97.

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