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Comment
. 2013 Jun;83(6):996-8.
doi: 10.1038/ki.2013.58.

How to find a prognostic biomarker for progressive diabetic nephropathy

Frank C Brosius  1 , Subramaniam Pennathur
Affiliations
Comment

How to find a prognostic biomarker for progressive diabetic nephropathy

Frank C Brosius et al. Kidney Int. 2013 Jun.

Abstract

As a prognostic biomarker for progression of diabetic nephropathy, albuminuria fails in terms of sensitivity and specificity. Better urinary or plasma biomarkers are needed that can predict which diabetic patients are at highest risk for progression. Bhensdadia et al. report proteomic investigations that identified urinary haptoglobin as a potential prognostic biomarker for progressive diabetic nephropathy. Although as a single marker urinary haptoglobin adds little to albuminuria, together the two appear to provide better diagnostic accuracy than albuminuria alone.

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Conflict of interest statement

Disclosures: Neither author has relevant conflicts. Dr. Brosius is participating in a clinical trial with Lilly and Co. and has consulting agreements through the University of Michigan with Lilly and Co. and Merck, Sharp and Dohme Research Laboratories.

Figures

Figure 1
Figure 1
Haptolglobin mRNA levels in microdissected glomeruli and tubulointerstitium from subjects with diabetic nephropathy compared to those from living transplant donors. Haptoglobin levels were 2.4-fold higher in the diabetic nephropathy subjects than in controls (p < 0.04). Levels in the tubulointerstitium were not statistically different though there were several diabetic subjects with substantially higher haptoglobin levels than in the controls. Nephromine™ was used for analysis and visualization. Nephromine is an online database of all published and some unpublished genome-wide expression data from human kidney studies and is freely available to all academic investigators (www.nephromine.org; Compendia Bioscience, Ann Arbor, MI) and is supported by the NIH O’Brien Kidney Core Center at the University of Michigan).
See this image and copyright information in PMC

Comment on

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