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. 2013 Sep;57(6):849-52.
doi: 10.1093/cid/cit376. Epub 2013 May 31.

Central nervous system herpes simplex and varicella zoster virus infections in natalizumab-treated patients

Andrew J Fine  1 , Alfred Sorbello, Cindy Kortepeter, Linda Scarazzini
Affiliations

Central nervous system herpes simplex and varicella zoster virus infections in natalizumab-treated patients

Andrew J Fine et al. Clin Infect Dis. 2013 Sep.

Abstract

We report on 20 natalizumab-treated patients with multiple sclerosis who developed laboratory-confirmed central nervous system (CNS) herpesvirus infections. In addition to progressive multifocal leukoencephalopathy, other CNS opportunistic infections have been rarely reported during natalizumab treatment. We encourage heightened awareness due to the risk for serious outcomes.

Keywords: HSV; VZV; encephalitis; meningitis; natalizumab.

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