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Comment
. 2013 Jun;15(6):570-2.
doi: 10.1038/ncb2777.

YAP forces fibroblasts to feel the tension

Ori Maller, Christopher C DuFort, Valerie M Weaver
Comment

YAP forces fibroblasts to feel the tension

Ori Maller et al. Nat Cell Biol. 2013 Jun.

Abstract

Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and remodelling. However, how CAFs become activated and their roles in tumour mechanics have remained unclear. YAP is now identified as a tension-stimulated CAF activator that promotes malignancy through a mechanically reinforced feed-forward loop.

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