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Comment
. 2013 Jun;15(6):575-7.
doi: 10.1038/ncb2770.

Job-splitting among integrins

Ronen Zaidel-Bar
Comment

Job-splitting among integrins

Ronen Zaidel-Bar. Nat Cell Biol. 2013 Jun.

Abstract

How different integrin receptors for the same extracellular ligand transduce distinct cellular responses is unclear. The characterization of the class-specific adhesomes of β1 and αV integrins now shows that whereas αV integrins promote unbranched actin polymerization, β1 integrins induce myosin-II-dependent contractility, and both integrin subtypes synergistically mediate rigidity sensing.

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References

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