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. 2013 May 31;2013(5):CD009190.
doi: 10.1002/14651858.CD009190.pub2.

Telephone delivered interventions for preventing HIV infection in HIV-negative persons

Michelle H M M T van-Velthoven  1 , Lorainne Tudor Car, Sarah Gentry, Josip Car
Affiliations

Telephone delivered interventions for preventing HIV infection in HIV-negative persons

Michelle H M M T van-Velthoven et al. Cochrane Database Syst Rev. .

Abstract

Background: This is one of the three Cochrane reviews that examine the role of the telephone in HIV/AIDS services. Although HIV infection can be prevented, still a large number of new infections occur. More effective HIV prevention interventions are needed to reduce the number of people newly infected with HIV. Phone calls can be used to potentially more effectively deliver HIV prevention interventions. They have the potential to save time, reduce costs and facilitate easier access.

Objectives: To assess the effectiveness of voice landline and mobile telephone delivered HIV prevention interventions in HIV-negative persons.

Search methods: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, PubMed Central, EMBASE, PsycINFO, Web of Science, Cumulative Index to Nursing & Allied Health, the World Health Organization's Global Health Library and Current Controlled Trials from 1980 to June 2011. We searched the following grey literature sources: Dissertation Abstracts International and the Centre for Agricultural Bioscience International Direct Global Health database, the System for Information on Grey Literature Europe, The Healthcare Management Information Consortium, Google Scholar, Conference on Retroviruses and Opportunistic Infections database, International AIDS Society conference database, AIDS Education Global Information System and reference lists of articles.

Selection criteria: Randomised controlled trials (RCTs), quasi-randomised controlled trials, controlled before and after studies, and interrupted time series studies comparing the effectiveness of delivering HIV prevention by phone calls to usual care in HIV-negative people regardless of their demographic characteristics and in all settings.

Data collection and analysis: Two reviewers independently searched databases, screened citations, assessed study quality and extracted data. A third reviewer resolved any disagreement. Primary outcomes were knowledge about the causes and consequences of HIV/AIDS, change in behaviour, healthcare uptake and clinical outcomes. Secondary outcomes were users' and providers' views on the intervention, economic outcomes and adverse outcomes.

Main results: Out of 14,717 citations, only one study met the inclusion criteria. The included RCT recruited women and girl children who received post-exposure prophylaxis (PEP) after rape from sexual assault services in South Africa between August 2007 and May 2008.Participants (n (number) =274) were randomised into a telephone support (n=136) and control (n=138) group. Control group participants received usual care (an interactive information session) from the sexual assault service during the 28 days in which they had to take PEP, with no further contact from the study staff. Telephone support group participants received standard care and phone calls from a counsellor throughout the 28 days when they had to take PEP.Overall, adherence to PEP was not significantly (P=0.13) different between the intervention (38.2%) and control (31.9 %) groups. Also, the proportion of participants who read a pamphlet, did not return to collect medication or with a depression were not significantly different between the intervention and control groups (P=0.006, P=0.42, P=0.72 respectively). The proportion of participants who used a diary was significantly (P=0.001) higher in the intervention group (78.8%) versus the control group (69.9%). The study authors reported that there were no recorded adverse events. The RCT did not provide information about participants' and providers' evaluation outcomes, or economic outcomes. The study had a moderate risk of bias.

Authors' conclusions: We found only one RCT, with a moderate risk of bias, which showed that providing PEP support by phone calls did not result in higher adherence to PEP. However, the RCT was conducted in an upper-middle-income country with high HIV prevalence, on a high-risk population and the applicability of its results on other settings and contexts is unclear. There is a need for robust evidence from various settings on the effectiveness of using phone calls for providing PEP support and for other HIV prevention interventions.

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Conflict of interest statement

None to declare.

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
See this image and copyright information in PMC

Update of

References

References to studies included in this review

Abrahams 2010a {published data only}
    1. Abrahams N, Jewkes R, Lombard C, Mathews S, Campbell J, Meel B. Impact of telephonic psycho‐social support on adherence to post‐exposure prophylaxis (PEP) after rape. AIDS Care 2010;22(10):1173‐81. - PubMed

References to studies excluded from this review

Orellana 2006 {published data only}
    1. Orellana ER, Picciano JF, Roffman RA, Swanson F, Kalichman SC. Correlates of nonparticipation in an HIV prevention program for MSM. AIDS Education and Prevention 2006;18(4):348‐61. - PubMed
Picciano 2001 {published data only}
    1. Picciano JF, Roffman RA, Kalichman SC, Rutledge SE, Berghuis J. A telephone based brief intervention using motivational enhancement to facilitate HIV risk reduction among MSM: A pilot study. AIDS and Behavior 2001;5(3):251‐62.
Picciano 2007 {published data only}
    1. Picciano JF, Roffman RA, Kalichman SC, Walker DD. Lowering obstacles to HIV prevention services: Effects of a brief, telephone‐based intervention using motivational enhancement therapy. Annals of Behavioral Medicine 2007;34(2):177‐87. - PMC - PubMed
Roffman 1997a {published data only}
    1. Roffman RA, Picciano JF, Ryan, R, Beadnell B, Fisher D, Downey L, et al. HIV‐prevention group counseling delivered by telephone: an efficacy trial with gay and bisexual men. AIDS and Behavior 1997;1(2):137‐54.
Roffman 1997b {published data only}
    1. Roffman RA, Picciano JF, Bolan M, Kalichman SC. Factors associated with attrition from an HIV‐prevention program for gay and bisexual males. AIDS and Behavior 1997;1(2):125‐35.
Roffman 1998 {published data only}
    1. Roffman RA, Picciano J, Wickizer L, Bolan M, Ryan R. Anonymous enrollment in AIDS prevention telephone group counseling: Facilitating the participation of gay and bisexual men in intervention and research. Journal of Social Service Research 1998;23(3‐4):5‐22.
Rutledge 2001 {published data only}
    1. Rutledge SE, Roffman RA, Mahoney C, Picciano JF, Berghuis JP, Kalichman SC. Motivational enhancement counseling strategies in delivering a telephone‐based brief HIV prevention intervention. Clinical Social Work Journal 2001;29(3):291‐306.

Additional references

Abrahams 2010b
    1. Abrahams N, Jewkes R. Barriers to post exposure prophylaxis (PEP) completion after rape: a South African qualitative study. Culture Health & Sexuality 2010;12(5):471‐84. - PubMed
Black 2011
    1. Black AD, Car J, Pagliari C, Anandan C, Cresswell K, Bokun T, et al. The impact of eHealth on the quality and safety of health care: a systematic overview. PLoS Medicine 2011; Vol. 8, issue 1:e1000387. - PMC - PubMed
Bos 2004
    1. Bos AE, Visser GC, Tempert BF, Schaalma HP. Evaluation of the Dutch AIDS information helpline: an investigation of information needs and satisfaction of callers. Patient Education and Counseling 2004;54(2):201‐6. - PubMed
Bunn 2005
    1. Bunn F, Byrne G, Kendall S. The effects of telephone consultation and triage on healthcare use and patient satisfaction: a systematic review. British Journal of General Practice 2005;55(521):956‐61. - PMC - PubMed
Car 2003
    1. Car J, Sheikh A. Telephone consultations. BMJ 2003;326(7396):966‐9. - PMC - PubMed
Car 2004
    1. Car J, Freeman GK, Partridge MR, Sheikh A. Improving quality and safety of telephone based delivery of care: teaching telephone consultation skills. Quality & Safety in Health Care 2004;13(1):2‐3. - PMC - PubMed
Cash‐Gibson 2012
    1. Cash‐Gibson L, Felix LM, Minorikawa N, Pappas Y, Gunn LH, Majeed A, et al. Automated telephone communication systems for preventive healthcare and management of long‐term conditions. Cochrane Database of Systematic Reviews 2012, Issue 7. [DOI: 10.1002/14651858.CD009921] - DOI - PMC - PubMed
Chacko 2012
    1. Chacko L, Ford N, Sbaiti M, Siddiqui R. Adherence to HIV post‐exposure prophylaxis in victims of sexual assault: a systematic review and meta‐analysis. Sexually Transmitted Infections 2012 Feb 13 [Epub ahead of print]. - PubMed
Department of Health South Africa 2010
    1. Department of Health South Africa. The 2010 National antenatal sentinel HIV & Syphilis prevalence survey in South Africa. http://www.health‐e.org.za/documents/85d3dad6136e8ca9d02cceb7f4a36145.pdf . Pretoria, 2010.
Djossa 2011
    1. Djossa Adoun MAS, Gagnon MP, Godin G, Tremblay N, Njoya MM, Ratté S, et al. Information and communication technologies (ICT) for promoting sexual and reproductive health (SRH) and preventing HIV infection in adolescents and young adults. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD009013] - DOI
Endnote X4 [Computer program]
    1. Thomson Reuters. Endnote. Version 4. Thomson Reuters, 2009.
EPOC 1998
    1. Cochrane Effective Practice and Organisation of Care Group. Draft EPOC Methods Paper: Including Interrupted Time Series (ITS) Designs in a EPOC Review. http://epoc.cochrane.org/sites/epoc.cochrane.org/files/uploads/inttime.pdf 1998.
EPOC 2002
    1. Cochrane Effective Practice and Organisation of Care Group. Cochrane Effective Practice and Organisation of Care Review Group: Data Collection Checklist. http://epoc.cochrane.org/sites/epoc.cochrane.org/files/uploads/datacolle... 2002.
EPOC 2009
    1. Cochrane Effective Practice and Organisation of Care Group. Risk of Bias. http://epoc.cochrane.org/epoc‐resources‐review‐authors 2009.
Fishbein 2000
    1. Fishbein M. The role of theory in HIV prevention. AIDS Care 2000;12(3):273‐8. - PubMed
Gentry 2013
    1. Gentry S, Velthoven MH, Tudor Car L, Car J. Telephone delivered interventions for reducing morbidity and mortality in people with HIV infection. Cochrane Database of Systematic Reviews 2013 . - PMC - PubMed
Higgins 2009
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. www.cochrane‐handbook.org .
Higgins 2011
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane‐handbook.org.
Higgs 2003
    1. Higgs R, Blache G, Peters M, Armstrong E, Jessopp L. Telephone consultation requires appropriate training. BMJ 2003;327(7405):53. - PMC - PubMed
Horvath 2012
    1. Horvath T, Azman H, Kennedy GE, Rutherford GW. Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection. Cochrane Database of Systematic Reviews 2012, Issue 3. [DOI: 10.1002/14651858.CD009756] - DOI - PMC - PubMed
ITU‐D 2011
    1. ITU‐D. The world in 2011 facts and figures. Available from http://www.itu.int/ITU‐D/ict/. Market Information and Statistics Division Telecommunication Development Bureau International Telecommunication Union (ITU), 2011.
Johnson 2008
    1. Johnson Wayne D, Diaz Rafael M, Flanders William D, Goodman M, Hill Andrew N, Holtgrave D, et al. Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database of Systematic Reviews 2008, Issue 3. [DOI: 10.1002/14651858.CD001230.pub2] - DOI - PubMed
Noar 2008
    1. Noar SM. Behavioral Interventions to Reduce HIV‐related Sexual Risk Behavior: Review and Synthesis of Meta‐Analytic Evidence. AIDS and Behavior 2008;12(3):335‐53. - PubMed
Noar 2009
    1. Noar SM, Black HG, Pierce LB. Efficacy of computer technology‐based HIV prevention interventions: a meta‐analysis. AIDS 2009;23(1):107‐15. - PubMed
Noar 2012
    1. Noar SM, Willoughby JF. eHealth interventions for HIV prevention. AIDS care 2012;24(8):945‐52. - PMC - PubMed
Okwundu 2012
    1. Okwundu Charles I, Uthman Olalekan A, Okoromah Christy AN. Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals. Cochrane Database of Systematic Reviews 2012, Issue 7. [DOI: 10.1002/14651858.CD007189.pub3] - DOI - PMC - PubMed
Sokol 2006
    1. Sokol D, Car J. Protecting patient confidentiality in telephone consultations in general practice. The British Journal of General Practice 2006;56(526):384‐5. - PMC - PubMed
Tudor Car 2013
    1. Tudor Car L, Gentry S, van‐Velthoven MH, Car J. Telephone communication of HIV testing results for improving knowledge of HIV infection status. Cochrane Database of Systematic Reviews 2013, Issue 1. [DOI: 10.1002/14651858.CD009192.pub2] - DOI - PubMed
UNAIDS 2002
    1. UNAIDS. HIV/AIDS Counselling, Just a Phone Call Away: four case studies of telephone hotline/helpline projects. http://www.unaids.org/en/media/unaids/contentassets/dataimport/publicati... . Geneva: UNAIDS, 2002.
van Velthoven 2012
    1. Velthoven MH, Tudor Car L, Car J, Atun R. Telephone consultation for improving health of people living with or at risk of HIV: a systematic review. PLoS One 2012;7(5):e36105. - PMC - PubMed
van Velthoven 2013
    1. Velthoven MH, Brusamento S, Majeed A, Car J. Scope and effectiveness of mobile phone messaging for HIV/AIDS care: A systematic review. Psychology, health & medicine 2013;18(2):182‐202. - PubMed
Vodopivec‐Jamsek 2012
    1. Vodopivec‐Jamsek V, Jong T, Gurol‐Urganci I, Atun R, Car J. Mobile phone messaging for preventive health care. Cochrane Database of Systematic Reviews 2012, Issue 12. [DOI: 10.1002/14651858.CD007457.pub2] - DOI - PMC - PubMed
Wariki 2012
    1. Wariki Windy MV, Ota E, Mori R, Koyanagi A, Hori N, Shibuya K. Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in low‐ and middle‐income countries. Cochrane Database of Systematic Reviews 2012, Issue 2. [DOI: 10.1002/14651858.CD005272.pub3] - DOI - PMC - PubMed
Weissman 1977
    1. Weissman MM, Sholomskas D, Pottenger M, Prusoff BA, Locke BZ. Assessing depressive symptoms in five psychiatric populations: a validation study. American Journal of Epidemiology 1977;106(3):203‐14. - PubMed
WHO 2010a
    1. WHO. Priority Interventions HIV/AIDS prevention, treatment and care in the health sector. Publications of the WHO are available on the WHO web site (www.who.int).. HIV/AIDS Department, 2010.
WHO 2010b
    1. WHO. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2010. Publications of the WHO are available on the WHO web site (www.who.int). 2010.
WHO 2011
    1. WHO. Global HIV/AIDS response: epidemic update and health sector progress towards universal access: progress report 2011. Publications of the WHO are available on the WHO web site (www.who.int). 2011.
Young 2007
    1. Young TN, Arens FJ, Kennedy GE, Laurie JW, Rutherford GW. Antiretroviral post‐exposure prophylaxis (PEP) for occupational HIV exposure. Cochrane Database of Systematic Reviews 2007, Issue 1. [DOI: 10.1002/14651858.CD002835.pub3] - DOI - PMC - PubMed

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