Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jun;18(6):707-16.
doi: 10.1634/theoncologist.2013-0063. Epub 2013 May 31.

Genomics of squamous cell lung cancer

Melissa Rooney  1 , Siddhartha Devarakonda, Ramaswamy Govindan
Affiliations
Review

Genomics of squamous cell lung cancer

Melissa Rooney et al. Oncologist. 2013 Jun.

Abstract

Approximately 30% of patients with non-small cell lung cancer have the squamous cell carcinoma (SQCC) histological subtype. Although targeted therapies have improved outcomes in patients with adenocarcinoma, no agents are currently approved specifically for use in SQCC. The Cancer Genome Atlas (TCGA) recently published the results of comprehensive genomic analyses of tumor samples from 178 patients with SQCC of the lung. In this review, we briefly discuss key molecular aberrations reported by TCGA and other investigators and their potential therapeutic implications. Carefully designed preclinical and clinical studies based on these large-scale genomic analyses are critical to improve the outcomes of patients with SQCC of lung in the near future.

PubMed Disclaimer

Conflict of interest statement

Disclosures of potential conflicts of interest may be found at the end of this article.

Figures

Figure 1.
Figure 1.
Druggable genetic alterations in squamous cell carcinoma: The Cancer Genome Atlas data. Reprinted from [8] with permission. Abbreviation: MA F impact: Functional impact of mutation determined by Mutation Assessor score.
Figure 2.
Figure 2.
Schematic representation of possible genetic alterations that correlate with SQCC progression [6, 13, 16, 139]. Adapted from Wistuba et al. and Drilon et al. Abbreviation: LOH: loss of heterozygosity.
See this image and copyright information in PMC

References

    1. Howlader NNA, Krapcho M, Neyman N, et al. Bethesda, MD: National Cancer Institute; 2012. SEER cancer statistics review, 1975–2009 (vintage 2009 populations)
    1. World Health Organization. Cancer Fact Sheet Number 297. Geneva, Switzerland: World Health Organization; 2012.
    1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11–30. - PubMed
    1. Navada S, Lai P, Schwartz A, et al. Temporal trends in small cell lung cancer: Analysis of the national Surveillance Epidemiology and End-Results (SEER) database. J Clin Oncol. 2006;24(suppl 18):384S.
    1. Molina JR, Yang P, Cassivi SD, et al. Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83:584–594. - PMC - PubMed

MeSH terms

Substances