Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Jun 11;110(24):9629-30.
doi: 10.1073/pnas.1307485110. Epub 2013 May 31.

The cost of efficiency in energy metabolism

Affiliations
Comment

The cost of efficiency in energy metabolism

Arion I Stettner et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Structural differences between the ED and EMP pathways. This simplified diagram focuses on a few key aspects of the ED and EMP pathways (i.e., the flow of carbon and phosphate groups) to highlight the different organization of ATP-consuming and ATP-producing steps, leading to different ATP yields. Other important details (such as the stoichiometry of reducing equivalents NADH and NADPH) can be found in traditional depictions of these pathways. G6P, glucose 6-phosphate; F1,6BP, fructose 1,6-bisphosphate; G3P, glyceraldehyde 3-phosphate; Pi, inorganic phosphate.

Comment on

References

    1. White D. The Physiology and Biochemistry of Prokaryotes. Oxford: Oxford Univ Press; 2006.
    1. Flamholz A, Noor E, Bar-Even A, Liebermeister W, Milo R. Glycolytic strategy as a tradeoff between energy yield and protein cost. Proc Natl Acad Sci USA. 2013;110:10039–10044. - PMC - PubMed
    1. Romano AH, Conway T. Evolution of carbohydrate metabolic pathways. Res Microbiol. 1996;147(6–7):448–455. - PubMed
    1. Westerhoff HV, Hellingwerf KJ, Van Dam K. Thermodynamic efficiency of microbial growth is low but optimal for maximal growth rate. Proc Natl Acad Sci USA. 1983;80(1):305–309. - PMC - PubMed
    1. Pfeiffer T, Schuster S, Bonhoeffer S. Cooperation and competition in the evolution of ATP-producing pathways. Science. 2001;292(5516):504–507. - PubMed

MeSH terms

LinkOut - more resources