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Comparative Study
. 2012 Dec;53(12):1285-8.

Measurement of vitamin A, vitamin E, selenium, and L-lactate in dogs with and without osteoarthritis secondary to ruptured cranial cruciate ligament

Alexander de Oliveira El-Warrak  1 , Mouhamed Rouma, Audrey Amoroso, Soren R Boysen, Younés Chorfi
Affiliations
Comparative Study

Measurement of vitamin A, vitamin E, selenium, and L-lactate in dogs with and without osteoarthritis secondary to ruptured cranial cruciate ligament

Alexander de Oliveira El-Warrak et al. Can Vet J. 2012 Dec.

Abstract
in English, French

This study compared vitamin A, vitamin E, selenium (Se), and L-lactate in blood and synovial fluid in 2 groups of 6 dogs; a control group (without OA) and an osteoarthritic group with spontaneous cranial cruciate ligament rupture and OA. Concentrations of vitamin E were significantly higher in serum than in synovial fluid in both OA (P = 0.006) and control (P = 0.0008) groups. Vitamin E concentration in synovial fluid was significantly higher in the OA group than in the control group (P = 0.009). Concentrations of Se were significantly higher in serum than in synovial fluid in both OA (P = 0.003) and control (P = 0.0006) groups. There were no significant differences in levels of Se, vitamin A, and L-lactate between the 2 groups. This is the first study to show an increased concentration of vitamin E in the synovial fluid of dogs with OA compared with dogs that did not have OA.

Mesure de la vitamine A, de la vitamine E, du sélénium et de L-lactate chez les chiens avec ou sans ostéo-arthrite causée par la rupture d’un ligament croisé crânial. Cette étude a comparé lesmesures de vitamine A, de vitamine E, de sélénium (Se) et de L-lactate dans le sang et le liquide synovial chez 2 groupes de 6 chiens; un groupe témoin (sans ostéo-arthrite) et un groupe atteint d’ostéo-arthrite présentant une rupture spontanée du ligament croisé crânial et de l’ostéo-arthrite. Les concentrations de vitamine E étaient significativement plus élevées dans le sérum que dans le liquide synovial du groupe atteint d’ostéo-arthrite OA (P = 0,006) et du groupe témoin (P = 0,0008). La concentration de vitamine E dans le liquide synovial était significativement supérieure dans le groupe atteint d’ostéo-arthrite que dans le groupe témoin (P = 0,009). Les concentrations de Se étaient significativement plus élevées dans le sérum que dans le liquide synovial du groupe atteint d’ostéo-arthrite (P = 0,003) et du groupe témoin (P = 0,0006). Il n’y avait pas de différences significatives dans les niveaux de Se, de vitamine A et de L-lactate entre les deux groupes. Il s’agit de la première étude pour démontrer une concentration accrue de vitamine E dans le liquide synovial des chiens atteints d’ostéo-arthrite comparativement à des chiens qui n’avaient pas l’ostéo-arthrite.(Traduit par Isabelle Vallières).

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