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Clinical Trial
. 2013 Jun;27(3):167-71.
doi: 10.3341/kjo.2013.27.3.167. Epub 2013 Apr 8.

The effect of topical cyclosporine 0.05% on dry eye after cataract surgery

Yeon Woong Chung  1 , Tae Hoon Oh, Sung Kun Chung
Affiliations
Clinical Trial

The effect of topical cyclosporine 0.05% on dry eye after cataract surgery

Yeon Woong Chung et al. Korean J Ophthalmol. 2013 Jun.

Abstract

Purpose: To evaluate the effectiveness of cyclosporine 0.05% for dry eye after cataract surgery.

Methods: Thirty-two newly diagnosed patients with dry eye syndrome 1 week after cataract surgery received a twice-daily treatment of cyclosporine 0.05% for one eye and normal saline 0.9% for the other. Disease severity was measured at 2 weeks, 1 month, 2 months, and 3 months by Schirmer test I (ST-I), tear film break-up time (tBUT), corneal temperature and dry eye symptom questionnaire (Ocular Surface Disease Index).

Results: Both groups increased in ST-I and tBUT over time. ST-I in the cyclosporine 0.05% group showed a significant increase at 3 months and tBUT in the cyclosporine 0.05% group showed an increase at 2 and 3 months. The dry eye symptom score was significantly reduced in the cyclosporine 0.05% group.

Conclusions: Cyclosporine 0.05% can also be an effective treatment for dry eye after cataract surgery.

Keywords: Cataract surgery; Cyclosporine; Dry eye syndromes.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Changes of Schirmer test I score over time in the cyclosporine 0.05% and normal saline 0.9% groups.
Fig. 2
Fig. 2
Changes of tear film break-up time in the cyclosporine 0.05% and normal saline 0.9% groups over time.
Fig. 3
Fig. 3
Changes of corneal temperature in the two groups.
Fig. 4
Fig. 4
Changes of symptom severity score in the two groups. (A) Intensity score, (B) frequency score, and (C) aggravation score.
See this image and copyright information in PMC

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