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. 2013 Jun;5(3):153-9.
doi: 10.1177/1756287212471095.

Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

Tariq S Hakky  1 , Americo A Gonzalvo, Jorge L Lockhart, Alejandro R Rodriguez
Affiliations

Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

Tariq S Hakky et al. Ther Adv Urol. 2013 Jun.

Abstract

The objective of this review is to discuss the unique nature of primary renal Ewing sarcoma, including incidence, presentation and management. We also report on a common pattern of presentation, consisting of acute flank pain mimicking a renal stone colic, with or without hydronephrosis, and a renal mass discovered during imaging studies of renal Ewing sarcoma. We present our case of renal Ewing sarcoma along with imaging and pathological analysis. We also performed a retrospective review of all cases of renal Ewing sarcoma using PubMed. A total of 48 cases of renal EWS sarcoma have been reported and analyzed in this review. A mean age of 30.4 years was found along with a 61% male predominance. The mean survival was 26.14 months with a lower median survival in patients with advanced metastatic disease. Primary Ewing sarcoma of the kidney is rare. The diagnosis of primary renal EWS can be difficult and is based on a combination of electron microscopy, immunohistochemistry, chromosomal analysis, fluorescence in situ hybridization (FISH) and light microscopy.

Keywords: Ewing sarcoma; partial nephrectomy; primitive neuroectoderm tumors; renal; renal Ewing sarcoma.

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Conflict of interest statement

Conflict of interest statement: The authors declare no conflicts of interest in preparing this article.

Figures

Figure 1.
Figure 1.
Parasaggital view demonstrating the left lower pole renal mass with hydronephrosis.
Figure 2.
Figure 2.
CT scan showing the 5.8 cm × 4.3 cm left lower pole renal mass.
Figure 3.
Figure 3.
Hematoxylin and eosin stain at 400× magnification with round to oval nuclei with finely dispersed chromatin and scant ill-defined cytoplasm.
Figure 4.
Figure 4.
The cells at 400× magnification staining positive for CD99.
See this image and copyright information in PMC

References

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