Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 May 17:3:126.
doi: 10.3389/fonc.2013.00126. eCollection 2013.

Stereotactic body radiotherapy for treatment of squamous cell carcinoma of the tongue associated with human papilloma virus: a case report

Brian Rodgers  1 , Prakash Neupane, Chris Lominska, Yelizaveta Shnayder
Affiliations

Stereotactic body radiotherapy for treatment of squamous cell carcinoma of the tongue associated with human papilloma virus: a case report

Brian Rodgers et al. Front Oncol. .

Abstract

Stereotactic body radiotherapy (SBRT) has emerged as a treatment for recurrent squamous cell carcinoma of the head and neck in the field of prior radiation. We report a case of its use in an human papilloma virus (HPV) positive patient with squamous cell carcinoma of the right base of tongue. The patient had complete response to treatment and modest toxicities were noted. This represents encouraging results that SBRT is also useful for salvage in patients with HPV positive disease.

Keywords: HPV; SBRT; oropharyngeal cancer; recurrence; tongue neoplasms.

PubMed Disclaimer

Figures

Figure 1
Figure 1
CT neck of the neck with contrast, prior to treatment, demonstrates a submucosal irregularity that was ultimately biopsied and diagnosed as recurrent squamous cell carcinoma.
Figure 2
Figure 2
After a 2-week course of stereotactic radiation, CT scan of the neck with contrast showing complete response to therapy.
Figure 3
Figure 3
The initial IMRT plan isodose lines (with the doses in the upper left corner).
Figure 4
Figure 4
The SRT plan isodose lines (with doses bottom right).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Ang K. K., Sturgis E. M. (2012). Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. Semin. Radiat. Oncol. 22, 128–14210.1016/j.semradonc.2011.12.004 - DOI - PubMed
    1. Comet B., Kramar A., Faivre-Pierret M., Dewas S., Coche-Dequeant B., Degardin M., et al. (2012). Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study. Int. J. Radiat. Oncol. Biol. Phys. 84, 203–20910.1016/j.ijrobp.2012.07.526 - DOI - PubMed
    1. Heron D. E., Ferris R. L., Karamouzis M., Andrade R. S., Deeb E. L., Burton S., et al. (2009). Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase 1 dose escalation trial. Int. J. Radiat. Oncol. Biol. Phys. 75, 1493–150010.1016/j.ijrobp.2009.07.1124 - DOI - PubMed
    1. Roh K. W., Jang J. S., Kim M. S., Sun D. I., Kim B. S., Jung S. L., et al. (2009). Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 74, 1348–135510.1016/j.ijrobp.2008.10.013 - DOI - PubMed
    1. Rwigema J. C., Heron D. E., Ferris R. L., Andrade R. S., Gibson M. K., Yang Y., et al. (2011). The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy. Am. J. Clin. Oncol. 34, 372–37910.1097/COC.0b013e3181e84dc0 - DOI - PMC - PubMed

LinkOut - more resources