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. 2013 Jul 11;49(54):6102-4.
doi: 10.1039/c3cc41249k.

Copper-catalyzed sulfonamides formation from sodium sulfinates and amines

Xiaodong Tang  1 , Liangbin Huang, Chaorong Qi, Xia Wu, Wanqing Wu, Huanfeng Jiang
Affiliations

Copper-catalyzed sulfonamides formation from sodium sulfinates and amines

Xiaodong Tang et al. Chem Commun (Camb). .

Abstract

A new and convenient method for the construction of sulfonamides via a copper-catalyzed oxidative coupling between sodium sulfinates and amines with 1 atm O2 or DMSO as the oxidant was described. This method provides efficient and robust synthesis of functional sulfonamides in good yields and excellent chemoselectivity. And detailed mechanistic studies showed that this transformation may go through a single electron transfer (SET) pathway.

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