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Review
. 2013 Jun;15(6):380-8.
doi: 10.1111/jch.12089. Epub 2013 Apr 1.

Telmisartan/Hydrochlorothiazide combination therapy for the treatment of hypertension: a pooled analysis in older and younger patients

Sverre E Kjeldsen  1 , Helmut Schumacher, Steen Neldam, Robert M Guthrie
Affiliations
Review

Telmisartan/Hydrochlorothiazide combination therapy for the treatment of hypertension: a pooled analysis in older and younger patients

Sverre E Kjeldsen et al. J Clin Hypertens (Greenwich). 2013 Jun.

Abstract

Older patients frequently receive angiotensin II receptor blocker/diuretic combinations to control blood pressure (BP), although there have been relatively few trials specifically examining this patient population. A pooled analysis was performed of data from 7 randomized trials of telmisartan/hydrochlorothiazide combinations or telmisartan monotherapy in older (65 years and older) and younger (younger than 65 years) patients to better understand the response of older patients to a telmisartan/hydrochlorothiazide combination. Telmisartan doses were 40 mg and 80 mg (T40 and T80). Hydrochlorothiazide doses were 12.5 mg and 25 mg (H12.5 and H25). A total of 3654 patients were included and the mean treatment duration was approximately 8 weeks. BP reductions with telmisartan/hydrochlorothiazide combinations were broadly similar in older and younger patients. In older patients, mean BP reductions from baseline were -30.1/-19.0 mm Hg with the T80/H25 combination and -21.7/-13.0 mm Hg with T80 monotherapy. Tolerability was similar regardless of age, and the incidence of adverse events in both older and younger patients was similar to placebo. The telmisartan/hydrochlorothiazide combination, particularly high-dose T80/H25, is effective and well tolerated in patients 65 years and older as well as in younger patients.

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Figures

Figure 1
Figure 1
SBP mean (SD) change from baseline, according to baseline SBP category and age group, in hypertensive patients. H12.5 indicates hydrochlorothiazide 12.5 mg; H25, hydrochlorothiazide 25 mg; SBP, systolic blood pressure; SD, standard deviation; T40, telmisartan 40 mg; T80, telmisartan 80 mg.Younger: <65 years; older: ≤65 years..
Figure 2
Figure 2
DBP mean (SD) change from baseline, according to baseline DBP category and age group, in hypertensive patients. DBP indicates diastolic blood pressure; H12.5, hydrochlorothiazide 12.5 mg; H25, hydrochlorothiazide 25 mg; SD, standard deviation; T40, telmisartan 40 mg; T80, telmisartan 80 mg.Younger: <65 years; older: ≤65 years.
Figure 3
Figure 3
PP mean (SD) change from baseline, according to baseline PP category and age group, in hypertensive patients. H12.5 indicates hydrochlorothiazide 12.5 mg; H25, hydrochlorothiazide 25 mg; PP, pulse pressure; SD, standard deviation; T40, telmisartan 40 mg; T80, telmisartan 80 mg. Younger: <65 years; older: ≤65 years.
See this image and copyright information in PMC

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