doi: 10.1111/j.1365-3083.1975.tb02602.x.
Local graft-versus-host-reaction in mice specifically inhibited by anti-receptor antibodies
- PMID: 237319
- DOI: 10.1111/j.1365-3083.1975.tb02602.x
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Local graft-versus-host-reaction in mice specifically inhibited by anti-receptor antibodies
Scand J Immunol.
1975.
Abstract
The local graft-versus-host (GVH) reaction provoked by parental spleen cells in F1 mice was shown to be T-cell-dependent. GVH reactions were suppressed in F1 hybrid mice immunized with parental T lymphocytes of the same genotype, but not in F1 mice immunized with parental B cells. In some cases this immunity could be passively transferred by serum into normal F1 mice. The specific activity of such sera could be removed by absorption with either parental T or B cells. Some of the F1 antisera were specificlly cytotoxic for parental GVH-reactive lymphocytes.
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