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Comment
. 2013 Jul;14(7):579-80.
doi: 10.1038/embor.2013.74. Epub 2013 Jun 4.

A dual role of SNAP-25 as carrier and guardian of synaptic transmission

Gaga Kochlamazashvili  1 , Volker Haucke
Affiliations
Comment

A dual role of SNAP-25 as carrier and guardian of synaptic transmission

Gaga Kochlamazashvili et al. EMBO Rep. 2013 Jul.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Effect of presynaptic SNAP-25 levels on calcium-induced glutamate release. Top: in wild-type (WT) neurons, SNARE-mediated calcium-triggered synaptic vesicle fusion is negatively regulated by complex formation between SNAP-25 and VGCCs. Bottom: reduced SNAP-25 expression in heterozygotes (Het;+/−) partly releases VGCCs from SNAP-25-mediated clamping, resulting in elevated calcium influx through VGCCs and increased glutamate release through SNARE-mediated calcium-triggered synaptic vesicle fusion. Note that many key exocytotic proteins have been omitted for clarity. SNAP-25, synaptosomal-associated protein of 25 kDa; SNARE, soluble NSF attachment protein receptor; VGCC. voltage-gated calcium channel.
See this image and copyright information in PMC

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References

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