Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jun-Jul;22 Suppl 5(0 5):S46-8.
doi: 10.1097/IJG.0b013e3182934b6b.

Cerebral blood flow in glaucoma patients

Alon Harris  1 , Brent Siesky, Barbara Wirostko
Affiliations
Review

Cerebral blood flow in glaucoma patients

Alon Harris et al. J Glaucoma. 2013 Jun-Jul.

Erratum in

  • J Glaucoma. 2013 Sep;22(7):598. Siesky, Brent [added]

Abstract

Glaucomatous damage has been described as a slowly progressive neuronal degenerative process along the visual pathway. Decreased cerebral and ocular blood flow as well as impaired vascular autoregulation has been identified in glaucoma and have been shown to correlate with visual field loss. In low-tension glaucoma patients, diffuse cerebral ischemic changes have been detected through magnetic resonance imaging. Given these findings, it seems that for some patients, glaucomatous damage may be the ocular manifestation of a more widespread vascular abnormality involving the brain rather than a separate process isolated only to the eye and its immediate vasculature.

PubMed Disclaimer

Conflict of interest statement

Disclosure: The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mean blood flow velocities in the middle cerebral artery (MCA) in patients with glaucoma and in those with normal eyes. MCA mean velocity was statistically significantly lower in glaucoma patients than in controls. Adapted from Harris A, Zarfati D, Zalish M, et al. Am J Ophthalmol 2003;135:144–147.
See this image and copyright information in PMC

References

    1. Martinez A, Sanchez M. Ocular blood flow in glaucoma. Br J Ophthalmol. 2008;92:301–1302. - PubMed
    1. Martinez A, Sanchez M. Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma. Eye (Lond) 2008;22:515–520. - PubMed
    1. Yücel YH, Zhang Q, Gupta N, et al. Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch Ophthalmol. 2000;118:378–384. - PubMed
    1. Yücel YH, Zhang Q, Weinreb RN, et al. Atrophy of relay neurons in magno- and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci. 2001;42:3216–3222. - PubMed
    1. Weber AJ, Chen H, Hubbard WC, et al. Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci. 2000;41:1370–1379. - PubMed

Publication types

MeSH terms