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. 2013 Jun 28;76(6):1166-74.
doi: 10.1021/np400276q. Epub 2013 Jun 4.

Bioactive limonoid and triterpenoid constituents of Turraea pubescens

Chun-Mao Yuan  1 , Gui-Hua Tang, Yu Zhang, Xiao-Ying Wang, Ming-Ming Cao, Feng Guo, Yan Li, Ying-Tong Di, Shun-Lin Li, Hui-Ming Hua, Hong-Ping He, Xiao-Jiang Hao
Affiliations

Bioactive limonoid and triterpenoid constituents of Turraea pubescens

Chun-Mao Yuan et al. J Nat Prod. .

Abstract

Eleven new limonoids, turrapubins A-K (1-11), and three new triterpenoids (12-14), along with 14 known compounds, were isolated from the twigs of Turraea pubescens. The structures of 1-14 were elucidated on the basis of NMR and MS analysis. Compounds 12, 16, 18, and 19 exhibited inhibitory activities against lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. In addition, compounds 2, 11, 18, and 26 exhibited inhibitory activities against brine shrimp larvae (Artemia salina) at 100 ppm with the corrected mortality ranging from 81.7% to 100%.

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