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. 2013 Aug 15;261(1-2):108-19.
doi: 10.1016/j.jneuroim.2013.05.004. Epub 2013 Jun 2.

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Kati Tillack  1 , Matthias Naegele, Cathleen Haueis, Sven Schippling, Klaus-Peter Wandinger, Roland Martin, Mireia Sospedra
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Free article

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Kati Tillack et al. J Neuroimmunol. .
Free article

Abstract

Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

Keywords: Gender; Multiple sclerosis; Neutrophil; Neutrophil extracellular traps (NETs).

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