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Review
. 2013 Jun;34(6):747-54.
doi: 10.1038/aps.2013.50.

Mesenchymal stem cells: a new trend for cell therapy

Xin Wei  1 , Xue Yang, Zhi-peng Han, Fang-fang Qu, Li Shao, Yu-fang Shi
Affiliations
Review

Mesenchymal stem cells: a new trend for cell therapy

Xin Wei et al. Acta Pharmacol Sin. 2013 Jun.

Abstract

Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. In this review, we summarize the recent opinions on methods, timing and cell sources for MSC administration in clinical applications, and provide an overview of mechanisms that are significant in MSC-mediated therapies. Although MSCs for cell therapy have been shown to be safe and effective, there are still challenges that need to be tackled before their wide application in the clinic.

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Figures

Figure 1
Figure 1
Number of registered clinical trials of mesenchymal stem cells-based therapy on ClinicalTrials.gov.
Figure 2
Figure 2
Clinical phages of mesenchymal stem cells-based therapy. Data from ClinicalTrials.gov.
Figure 3
Figure 3
Percentages of the common diseases now treated with mesenchymal stem cells. Data from ClinicalTrials.gov.
See this image and copyright information in PMC

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