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. 2013 Nov;120(11):1605-9.
doi: 10.1007/s00702-013-1049-2. Epub 2013 Jun 5.

Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats

Dragos Inta  1 , Peter Renz, Juan M Lima-Ojeda, Christof Dormann, Peter Gass
Affiliations

Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats

Dragos Inta et al. J Neural Transm (Vienna). 2013 Nov.

Abstract

The glutamate hypothesis of schizophrenia postulates NMDA receptor hypofunction as important pathophysiological mechanism. In rodents, NMDA receptor antagonists induce together with psychosis-like effects cortical injury. Stress during adolescence can trigger schizophrenia by unknown mechanisms. Here we show in rats that juvenile chronic isolation significantly increases MK-801-triggered expression of heat shock protein 70, a marker of neuronal injury, in the retrosplenial cortex. These data suggest an additive effect of juvenile stress and NMDA receptor blockade, with possible relevance for schizophrenia.

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References

    1. J Neurosci Res. 1992 Dec;33(4):605-16 - PubMed
    1. J Pharmacol Exp Ther. 1998 Dec;287(3):839-46 - PubMed
    1. J Psychopharmacol. 2011 Dec;25(12):1720-9 - PubMed
    1. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1173-7 - PubMed
    1. Neurosci Biobehav Rev. 2010 Mar;34(3):285-94 - PubMed

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