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Meta-Analysis
. 2013 Sep;30(9):1239-44.
doi: 10.1007/s10815-013-0018-x. Epub 2013 Jun 5.

Is there a role for DHEA supplementation in women with diminished ovarian reserve?

Mazen R Fouany  1 , Fady I Sharara
Affiliations
Meta-Analysis

Is there a role for DHEA supplementation in women with diminished ovarian reserve?

Mazen R Fouany et al. J Assist Reprod Genet. 2013 Sep.

Abstract

Purpose: Poor ovarian reserve and poor ovarian response presents a challenge to IVF centers. Dehydroepiandrosterone (DHEA) supplementation is increasingly being used by many IVF centers around the world in poor responders despite the lack of convincing data. We therefore examined the rationale for the use of DHEA in poor responders, address the relevant studies, present new data, and address its potential mechanisms of action.

Methods: All published articles on the role of DHEA in infertile women from 1990 to April 2013 were reviewed.

Results: Several studies have suggested an improvement in pregnancy rates with the use of DHEA. Potential mechanisms include improved follicular steroidogenesis, increased IGF-1, acting as a pre-hormone for follicular testosterone, reducing aneuploidy, and increasing AMH and antral follicle count. While the role of DHEA is intriguing, evidence-based recommendations are lacking.

Conclusions: While nearly 25 % of IVF programs use DHEA currently, large randomized prospective trials are sorely needed. Until (and if) such trials are conducted, DHEA may be of benefit in suitable, well informed, and consented women with diminished ovarian reserve.

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References

    1. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab. 2005;90:3847–53. doi: 10.1210/jc.2005-0212. - DOI - PubMed
    1. Baulieu EE. Dehydroepiandrosterone (DHEA): a fountain of youth? J Clin Endocrinol Metabo. 1996;81:3147–51. doi: 10.1210/jc.81.9.3147. - DOI - PubMed
    1. Richardson S, Senikas V, Nelson J. Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion. J Clin Endocrinol Metab. 1987;65:1231–7. doi: 10.1210/jcem-65-6-1231. - DOI - PubMed
    1. Sunkara SK, Coomarasamy A, Arlt W, Bhattacharya S. Should androgen supplementation be used for poor ovarian response in IVF? Hum Reprod. 2012;27:637–40. doi: 10.1093/humrep/der464. - DOI - PubMed
    1. Yakin K, Urman B. DHEA as a miracle drug in the treatment of poor responders; hype or hope? Hum Reprod. 2011;26:1941–4. doi: 10.1093/humrep/der150. - DOI - PubMed

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