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Review
. 2013:2013:895651.
doi: 10.1155/2013/895651. Epub 2013 May 7.

Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease

Francisca Cornejo  1 , Rommy von Bernhardi
Affiliations
Review

Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease

Francisca Cornejo et al. Mediators Inflamm. 2013.

Abstract

It is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer's disease. However, it is unknown how these cells initiate the response that results in cognitive impairment and neuronal degeneration. Here, we review the participation of the immune response mediated by glial cells in Alzheimer's disease and the role played by scavenger receptors in the development of this pathology, focusing on the relevance of class A scavenger receptor (SR-A) for A β clearance and inflammatory activation of glial cell, and as a potential target for Alzheimer's disease therapy.

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Figures

Figure 1
Figure 1
Summary of the main characteristics and functions played by SRs in inflammation and AD. The left panel shows changes induced by the inflammatory activation of SRs reviewed in the text. The right panel resumes the principal alterations induced by the activation of SRs mediated by the amyloid peptide.
See this image and copyright information in PMC

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