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. 2013:2013:905091.
doi: 10.1155/2013/905091. Epub 2013 May 2.

Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?

Iole Cucinotto  1 , Lucia Fiorillo, Simona Gualtieri, Mariamena Arbitrio, Domenico Ciliberto, Nicoletta Staropoli, Anna Grimaldi, Amalia Luce, Pierfrancesco Tassone, Michele Caraglia, Pierosandro Tagliaferri
Affiliations

Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?

Iole Cucinotto et al. J Drug Deliv. 2013.

Abstract

Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this innovative compound and report the recent changing-practice results in breast and pancreatic cancer. A ground-breaking finding is the demonstration that nab-paclitaxel can not only enhance the activity and reduce the toxicity of chromophore-diluted compound, but also exert activity in diseases considered refractory to taxane-based treatment. This is the first clinical demonstration of major activity of nanotechnologically modified drugs in the treatment of human neoplasms.

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Figures

Figure 1
Figure 1
Structure of paclitaxel (5β,20-epoxy-1,2α,4,7β,13α-hex-ahydroxytan-11-en-9-one-4,10-diacetate2-benzoate-13-ester with (2R.3S)-N-benzoyl-3-phenyllioserine).
Figure 2
Figure 2
Taxane nucleus.
See this image and copyright information in PMC

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