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. 2012 Feb 15;1(3):85-90.
Print 2011 Jul.

Oxidative system in aged skeletal muscle

Daniela Buonocore  1 , Sara Rucci, Matteo Vandoni, Massimo Negro, Fulvio Marzatico
Affiliations

Oxidative system in aged skeletal muscle

Daniela Buonocore et al. Muscles Ligaments Tendons J. .

Abstract

Aging is an inevitable biological process that is characterized by a general decline in the physiological and biochemical functions of the major systems. In the case of the neuromuscular system, reductions in strength and mobility cause a deterioration in motor performance, impaired mobility and disability. At the cellular level, aging is caused by a progressive decline in mitochondrial function that results in the accumulation of reactive oxygen species (ROS). As the level of oxidative stress in skeletal muscle increases with age, the age-process is characterized by an imbalance between an increase in ROS production in the organism, and antioxidant defences as a whole. We have reviewed the literature on oxidative stress in aging human skeletal muscles, and to assesss the impact of differences in physiological factors (sex, fiber composition, muscle type and function).

Keywords: ROS; aged skeletal muscle; markers of skeletal muscle aging; oxidative system; sarcopenia.

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