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. 2013 Jun 20;368(25):2345-8.
doi: 10.1056/NEJMp1307009. Epub 2013 Jun 5.

Pandemic influenza viruses--hoping for the road not taken

David M Morens  1 , Jeffery K Taubenberger, Anthony S Fauci
Affiliations

Pandemic influenza viruses--hoping for the road not taken

David M Morens et al. N Engl J Med. .
No abstract available

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Figures

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Origin of the Novel Avian Influenza A H7N9 Virus
On the basis of published sequences and phylogenetic analyses, it has been hypothesized that the novel avian H7N9 influenza virus is a reassortant virus containing gene segments derived from four separate avian influenza viruses, including two different wild-bird viruses contributing the H7 hemagglutinin (HA) (closest match to wild-duck virus) and N9 neuraminidase (NA) (closest match to a wild-bird isolate) gene segments, and two different domestic-poultry–derived H9N2 viruses contributing the other six “internal” genes (polymerase PB2, PB1, and PA genes), the nucleoprotein (NP) gene, and the matrix (M) and nonstructural (NS) genes. The avian origin of each of the eight H7N9 gene segments is coded by color. A representative H7N9 human isolate is marked with asterisks in the polymerase PB2 and HA genes to indicate key mutations associated with human adaptation.
See this image and copyright information in PMC

References

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