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. 2013 Jun;19(6):989-91.
doi: 10.3201/eid1906.121648.

Novel SARS-like betacoronaviruses in bats, China, 2011

Li Yang  1 , Zhiqiang Wu, Xianwen Ren, Fan Yang, Guimei He, Junpeng Zhang, Jie Dong, Lilian Sun, Yafang Zhu, Jiang Du, Shuyi Zhang, Qi Jin
Affiliations

Novel SARS-like betacoronaviruses in bats, China, 2011

Li Yang et al. Emerg Infect Dis. 2013 Jun.

Abstract

To clarify the evolutionary relationships among betavoronaviruses that infect bats, we analyzed samples collected during 2010-2011 from 14 insectivorous bat species in China. We identified complete genomes of 2 novel betacoronaviruses in Rhinolophus pusillus and Chaerephon plicata bats, which showed close genetic relationships with severe acute respiratory syndrome coronaviruses.

Keywords: China; Chiroptera; Coronavirus; SARS virus; bats; viruses.

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Figures

Figure 1
Figure 1
Phylogenetic tree of novel betacoronaviruses based on the nucleotide sequence of the RdRp gene. The following coronaviruses (CoVs) and GenBank accession numbers were used: bat severe acute respiratory syndrome CoV Rm1 (bat SARS-CoV Rm1; DQ412043), bat SARS-CoV Rp3 (DQ071615), bat SARS-CoV Rf1 (DQ412042), bat SARS-CoV HKU3 (DQ022305),SARS-CoV isolate Tor2/FP1–10895 (SARS-CoV Tor2; JX163925), SARS-CoV BJ182–12 (SARS-CoV BJ182; EU371564), SARS-CoV (NC004718), civet SARS-CoV SZ3 (AY304486), civet SARS-CoV SZ16 (AY304488), bat CoV HKU9 (BtCoV-HKU9; EF065513), bat CoV HKU4 (BtCoV-HKU4; EF065505), bat CoV HKU5 (BtCoV-HKU5; EF065509), human betacoronvirus 2c EMC/2012 (HCoV-EMC; JX869059), human CoV OC43 (HCoV-OC43; NC005147), HCoV-HKU1 (NC006577), bat coronavirus HKU2 (BtCoV-HKU2; NC009988), bat coronavirus 1A (BtCoV-1A; NC010437), HCoV-229E (NC002645), HCoV-NL63 (NC005831), bat CoV HKU8 (BtCoV-HKU8; NC010438), scotophilus bat CoV 512 (BtCoV-512; NC009657), avian infectious bronchitis virus (IBV; NC001451), beluga whale CoV SW1 (BWCoV; NC010646). Scale bar indicates genetic distance estimated by using TN93+G+I model implemented in MEGA5 (www.megasoftware.net).
Figure 2
Figure 2
Phylogenetic tree of novel betacoronaviruses based on the deduced amino acid sequence of spike protein. SARS, severe acute respiratory syndrome; CoV, coronavirus; HCoV, human CoV; BtCoV, bat CoV; BWCoV, beluga whale CoV; IBV, avian infectious bronchitis. Scale bar indicates genetic distance estimated by using WAG+G+I+F model implemented in MEGA5 (www.megasoftware.net).
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