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. 2013 Apr-Jun;20(2):174-8.
doi: 10.4103/0974-9233.110617.

Ocular blood flow velocity in primary open angle glaucoma--a tropical African population study

Odunlami Olufemi Adeyinka  1 , Ayoola Olugbenga, Onakpoya Oluwatoyin Helen, Adetiloye Victor Adebayo, Arogundade Rasheed
Affiliations

Ocular blood flow velocity in primary open angle glaucoma--a tropical African population study

Odunlami Olufemi Adeyinka et al. Middle East Afr J Ophthalmol. 2013 Apr-Jun.

Abstract

Purpose: To assess blood flow velocity in newly diagnosed indigenous black-skinned Africans with primary open angle glaucoma (POAG).

Materials and methods: Prospective case-control study at Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria on 50 newly diagnosed POAG patients (POAG group) and 50 control patients (control group). Ocular Doppler Color Imaging was performed on subjects in the supine position using 9 MHz linear array transducer of a Fukuda Denshi Ultrasound. The Peak Systolic Velocity (PSV) and End Diastolic Velocity (EDV) values were obtained by finding the average of two readings each for the ophthalmic artery (OA) and central retinal artery (CRA). Resistive Index (RI) was calculated as (PSV - EDV)/PSV. Data were analyzed and statistical significance was defined at P < 0.05.

Results: The mean intraocular pressure (IOP) for the POAG group and control group was 28.1 ± 7.4 mmHg and 16.6 ± 2.0 mmHg, respectively (P < 0.001). The mean PSV for OA was 31.35 cm/s in POAG group and 37.61 cm/s for the control group (P < 0.001). The EDV for both OA and CRA were significantly lower in glaucoma patients as compared with the corresponding values in the control group (P < 0.001, both comparisons). The mean RI in the OA was 0.71 ± 0.05 and 0.63 ± 0.03 for the POAG and control group groups, respectively (P < 0.001). The increase in IOP in the POAG group was statistically significantly negatively correlated with PSV and EDV and positively correlated with RI for both OA and CRA.

Conclusion: The outcomes of this study indicate that ocular blood flow alterations including reductions in PSV and EDV and increase in RI of the OA and CRA are present in black-skinned Africans with POAG.

Keywords: Black-skinned Africans; Case-Control; Case-Control Group; Glaucoma; Intraocular Pressure; Ocular Doppler; Resistive Index.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Relationship between end diastolic velocity (EDV) and intraocular pressure (IOP) in the ophthalmic artery (OA) of patients with primary open angle glaucoma (POAG)
Figure 2
Figure 2
Resistive index (RI) and intraocular pressure (IOP) in ophthalmic artery (OA) of POAG
Figure 3
Figure 3
Relationship between peak systolic velocity (PDV) and intraocular pressure (IOP) in the central retina artery (CRA)
Figure 4
Figure 4
Relationship between end diastolic velocity (EDV) and intraocular pressure (IOP) in the central retina artery (CRA)
See this image and copyright information in PMC

References

    1. Resnikoff S, Pascolin D, Etya’ale D, Kocur I, Pararajasegaram R, Pokharel GP, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;84:844–51. - PMC - PubMed
    1. Abdull MM, Sivasubramaniam S, Murthy GV, Gilbert C, Abubakar T, Ezelum C, et al. Causes of blindness and visual impairment in Nigeria: The Nigeria national blindness and visual impairment survey. Invest Ophthalmol Vis Sci. 2009;50:4114–20. - PubMed
    1. Onakpoya OH, Adeoye AO, Akinsola FB, Adegbehingbe BO. Prevalence of blindness and visual impairment in Atakunmosa West Local Government area of southwestern Nigeria. Tanzan Health Res Bull. 2007;9:126–31. - PubMed
    1. Adeoti CO. Prevalence and causes of blindness in a tropical African population. West Afr J Med. 2004;23:249–52. - PubMed
    1. Adeoye A. Survey of blindness in rural communities of south-western Nigeria. Trop Med Int Health. 1996;1:672–6. - PubMed

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