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. 2013 May;56(5):191-5.
doi: 10.3345/kjp.2013.56.5.191. Epub 2013 May 28.

Phenotypes and endotypes of severe asthma in children

Young Yoo  1
Affiliations

Phenotypes and endotypes of severe asthma in children

Young Yoo. Korean J Pediatr. 2013 May.

Abstract

Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identification of the phenotype clusters and endotypes of severe asthma can allow further modulation of the natural history of severe asthma and may provide the pathophysiologic rationale for appropriate management strategies.

Keywords: Child; Endotype; Phenotype; Severe asthma.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Hypothesized development of severe asthma in children. Reprinted from Fitzpatrick and Teague. Pediatr Allergy Immunol Pulmonol 2010;23:131-8, with permission of Mary Ann Liebert, Inc..
See this image and copyright information in PMC

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